Covid's Risk to Older Adults - The New York Times TN, NMF, WH, and SA wrote the software. Questions or messages regarding errors in formatting should be addressed to URL addresses listed in MMWR were current as of Med. Mortal. Omicron data in UK is 'enormously worrying,' immunologist says "In the last two weeks, no fewer than 80% of admissions were below the age of 50 years. Using previously described methods (3), investigators collected clinical data on a representative sample of adult patients (7.9%) hospitalized during July 1, 2021January 31, 2022, stratified by age and COVID-NET site. Hospitalization rates and characteristics of children aged <18 years hospitalized with laboratory-confirmed COVID-19COVID-NET, 14 States, March 1-July 25, 2020. J. Med. All rights Reserved. In the Omicron variant period, the effectiveness of maternal vaccination in these three age intervals was 21% (CI: 21,48), 14% (CI: 9,32) and 13% (CI: 3,26), respectively. Use the Previous and Next buttons to navigate the slides or the slide controller buttons at the end to navigate through each slide. The report shows people catching Omicron are: 31% to 45% less likely to go to A&E. 50% to 70% less likely to be admitted to hospital for treatment. 385, 13551371 (2021). wrote the initial manuscript. Immunogenicity and Reactogenicity of the Beta-variant Recombinant The vaccines have proved highly safe and effective at reducing the risk of severe illness, hospitalization and death. Corresponding author: Christopher A. Taylor, iyq3@cdc.gov. 552a; 44 U.S.C. Rates cannot be stratified by pregnancy status because the underlying population of pregnant women in the catchment area is unknown. We were not able to evaluate more detailed measures of relative clinical severity in hospitalised patients (such as intensive care unit admittance), but our finding that estimated severity reductions comparing omicron with delta are larger for more severe endpoints (death and hospital admission versus hospital attendance) agrees with observations that the proportion of hospitalised COVID-19 patients requiring intensive care or mechanical ventilation (or both) has been substantially lower during the omicron wave in England than the preceding delta wave. CIDRAP - Center for Infectious Disease Research & Policy With wave after wave of SARS-CoV-2 variants, COVID-19 patients filled the worlds' hospitals and morgues because not everybody had access to vaccines or were willing to be vaccinated. pdf files, Omicron: fewer adverse outcomes come with new dangers, Statement on offensive historical content, Redistribute or republish the final article, Reuse portions or extracts from the article in other works. and/or the original MMWR paper copy for printable versions of official text, figures, and tables. Vaccine 31, 21652168 (2013). Starting the week ending December 4, 2021, Maryland data are not included in calculations but are included in previous weeks. of pages found at these sites. The outcomes were the infants first positive nasal/throat swab for SARS-CoV-2 by PCR, and the first COVID-19-related hospitalization, occurring during the first 6 months of life and recorded in the electronic health record. Mothers were classified as either having had 2 doses or one dose of mRNA COVID-19 vaccines during pregnancy (and completed more than 14 days prior to delivery) or not having had any COVID-19 vaccines prior to delivery. Vaccine 35, 72977301 (2017). Garg S, Patel K, Pham H, et al. Wkly. We observed a similar pattern in vaccine effectiveness by trimester during the Omicron dominant period, however, estimates of vaccine effectiveness by trimester were imprecise and much lower than during the Delta period (Table3). Risk was especially high for people with severe combined immunodeficiency (HR, 6.2). The risk of hospitalisation appeared to increase when comparing delta with alpha infections. Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. These findings are consistent with the diminishing of pregnancy-derived antibodies in infants over time22. We also conducted analyses based on the trimester during which the vaccine was received during pregnancy (first, second, or third trimester). To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Lipkind, H. S. et al. Taken together, these findings suggest that the increased risk for hospitalization among Black adults during the Omicron-predominant period might also be due, in part, to lower proportions of Black adults receiving both the primary vaccination series and booster doses. COVID-19associated signs and symptoms included respiratory symptoms (congestion or runny nose, cough, hemoptysis or bloody sputum, shortness of breath or respiratory distress, sore throat, upper respiratory infection, influenza-like illness, and wheezing) and non-respiratory symptoms (abdominal pain, altered mental status or confusion, anosmia or decreased smell, chest pain, conjunctivitis, diarrhea, dysgeusia or decreased taste, fatigue, fever or chills, headache, muscle aches or myalgias, nausea or vomiting, rash, and seizures). Real-world data suggest lower COVID-19 vaccine effectiveness against Omicron variants11,12,13,14. It's not clear which variant might have been associated with these hospitalizations. Evaluation of the relative virulence of novel SARS-CoV-2 variants: a retrospective cohort study in Ontario, Canada. The Spanish Health Ministry also publishes hospitalization data throughout Spain broken down by vaccination status, although in this case it is based on estimates: to calculate the number of unvaccinated in each age group, they subtract the number of vaccinated from the population in 2020.However, the target population will have grown since then, so it is possible that the ministry's . Mortal. It is not inevitable that viral evolution leads to lower severity. Article New charts from the Centers for Disease Control and Prevention (CDC), more severe disease and more hospitalizations, Insider's Catherine Schuster Bruce reported. In-hospital death status was missing in 1.4% (weighted) of hospitalizations; these hospitalizations are otherwise included elsewhere in the analysis. In the US, as of the end of September 2022, almost 15 million children ages <18 years have tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes Coronavirus Disease 2019 (COVID-19). Association of COVID-19 vaccination during pregnancy with incidence of SARS-CoV-2 infection in infants. Viruses | Free Full-Text | SARS-CoV-2 Seroprevalence among Canadian Adults with no documented receipt of any COVID-19 vaccine dose before the test date were considered unvaccinated. Data among adults over 50 showed that a booster shot gave even stronger protection. . However, we have no reason to expect a strong association between the absence of NHS number and SARS-CoV-2 variant. COVID-19Associated Hospitalizations Among Adults During SARS-CoV-2 Delta and Omicron Variant Predominance, by Race/Ethnicity and Vaccination Status COVID-NET, 14 States, July 2021January 2022. Risk factors for severe COVID-19 in children. In all models, we used calendar days as the time scale to account for changes over time in SARS-CoV-2 circulation and vaccine uptake. If ethnicity was unknown, non-Hispanic ethnicity was assumed. There were only one hospitalized case among the children of vaccinated mothers and nine hospitalized cases among the children of unvaccinated mothers (Table1). Vaccine 35, 58505857 (2017). As infants aged, protection provided by maternal vaccination decreased during both periods. Infect. Vaccination status (unvaccinated, receipt of a primary series only, or receipt of a primary series plus a booster or additional dose) was determined for individual hospitalized patients and for the catchment population using state immunization information systems data (2). Requests for access to the underlying source data should be directed to UKHSA. Pregnant women were excluded because their reasons for hospital admission (4) might differ from those for nonpregnant persons. PubMed Central We ran separate models on the time periods associated with the Delta (7/01/2021 to 12/20/2021) and Omicron variants (12/21/2021 to 5/31/2022). N. Engl. Mortal. The difference between the two studies might be due to population characteristics and the timing of follow-up as ours went through May 31, 2022, while the Norwegian study ended in April 2022. Morb. B., Lewis. During the Omicron-predominant period, hospitalization rates increased among unvaccinated persons and those who completed a primary series, with and without receipt of a booster or additional dose (Figure 2). Trends in disease severity and health care utilization during the early Omicron variant period compared with previous SARS-CoV-2 high transmission periodsUnited States, December 2020January 2022. Sign up for the Nature Briefing newsletter what matters in science, free to your inbox daily. The final study population included 30311 (48.8%) infants who were KPNC members at least 2 months after birth. Methods: One hundred and . Gretchen Rothrock, California Emerging Infections Program; Millen Tsegaye, Colorado Department of Public Health and Environment; Julie Plano, Connecticut Emerging Infections Program, Yale School of Public Health; Kyle Openo, Georgia Emerging Infections Program, Georgia Department of Public Health Division of Infectious Diseases, School of Medicine, Emory University; Andy Weigel, Iowa Department of Health; Chloe Brown, Michigan Department of Health and Human Services; Erica Bye, Minnesota Department of Health; Wickliffe Omondi, New Mexico Emerging Infections Program, University of New Mexico; Alison Muse, New York State Department of Health; Christina Felsen, University of Rochester School of Medicine and Dentistry; Eli Shiltz, Ohio Department of Health; Nasreen Abdullah, Public Health Division, Oregon Health Authority; William Schaffner, Vanderbilt University Medical Center; Melanie Crossland, Salt Lake County Health Department. Vaccinated patients were older (68 vs. 57 years), and 62% had at least one comorbidity Admission to the ICU was 20%, and the mortality rate at 30 days was 14%. Vaccination status is based on state immunization information system data. Further information on research design is available in theNature Portfolio Reporting Summary linked to this article. However, in contrast with the Norwegian study which reported that infants of mothers who were vaccinated had a 33% decreased risk of testing positive during the first 4 months of life during the Omicron period17, our study found a 13% reduced risk that was not statistically significant. To update your cookie settings, please visit the, https://doi.org/10.1016/S0140-6736(22)00462-7, Comparative analysis of the risks of hospitalisation and death associated with SARS-CoV-2 omicron (B.1.1.529) and delta (B.1.617.2) variants in England: a cohort study, https://www.who.int/news/item/26-11-2021-classification-of-omicron-(b.1.1.529)-sars-cov-2-variant-of-concern, https://www.cdc.gov/coronavirus/2019-ncov/science/science-briefs/scientific-brief-omicron-variant.html, https://www.mrc-bsu.cam.ac.uk/now-casting/report-on-nowcasting-and-forecasting-9th-december-2021/, https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1050999/Technical-Briefing-35-28January2022.pdf, https://www.research.ed.ac.uk/en/publications/severity-of-omicron-variant-of-concern-and-vaccine-effectiveness-, https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/covid-19/report-50-severity-omicron/, https://doi.org/10.1101/2022.01.11.22269045, https://doi.org/10.1101/2022.01.12.22269179, https://doi.org/10.1101/2022.01.20.22269406, https://doi.org/10.1101/2022.01.12.22269148, https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1054071/vaccine-surveillance-report-week-6.pdf, https://www.gov.uk/government/publications/investigation-of-sars-cov-2-variants-routine-variant-data-update, https://www.gov.uk/government/publications/nhs-test-and-trace-statistics-england-methodology/nhs-test-and-trace-statistics-england-methodology, https://www.england.nhs.uk/contact-us/privacy-notice/national-flu-vaccination-programme/, https://digital.nhs.uk/data-and-information/data-collections-and-data-sets/data-sets/emergency-care-data-set-ecds, https://digital.nhs.uk/services/secondary-uses-service-sus, https://www.england.nhs.uk/statistics/statistical-work-areas/covid-19-hospital-activity/, https://doi.org/10.1101/2021.08.13.21262014, View Large Atlanta, GA: US Department of Health and Human Services, CDC; 2022. DeSilva, M. et al. Views equals page views plus PDF downloads. Coinciding with Omicron variant predominance, COVID-19associated hospitalization rates among adults increased in late December 2021 and peaked in January 2022; rates increased more among Black adults relative to rates among adults of other racial and ethnic groups. 3501 et seq. Methods: This is a retrospective cohort study that was conducted in Israel's second-largest . However, vaccination during pregnancy was less effective at protecting infants against SARS-CoV-2 infection during the Omicron period.